Inhaled insulin: A “puff” than a “shot” before meals

Adjunctive inhaled insulin before meals improved glycaemic control more than adjunctive metformin in type 2 diabetes mellitus.

M e t h o d s Design: Randomized controlled trial. Allocation: Concealed.* Blinding: Unblinded.* Follow-up period: 24 weeks. Setting: 13 centers in Europe, South Africa, Israel, and Brazil. Patients: 427 patients 35 to 80 years of age (mean age 60 y, 53% men) who had type 2 diabetes mellitus ≥ 6 months, were poorly controlled on sulfonylurea ≥ 2 months, and had normal pulmonary function test re...

Inhaled Insulin: A Clinical and Historical Review.

Insulin is the most effective blood glucose lowering agent and remains one of the cornerstones of diabetes management. However, many individuals with diabetes are either reluctant to initiate or are nonadherent to their insulin therapy for various reasons, including fear of frequent injections. Technosphere Insulin (TI) is a novel inhaled insulin powder that is approved by the United States Foo...

Inhaled human insulin: a clinical perspective

10.1586/14750708.3.3.339 © 2 Delivering insulin via the inhalation route is an exciting concept. Recent progress in inhalation technology has enabled development of inhaled insulin-delivery systems. Exubera® (inhaled human insulin; INH; insulin, human [rDNA origin] Inhalation Powder) is one of several inhaled insulins being developed, and is the first inhaled insulin to obtain regulatory approv...

Overall satisfaction increased more with inhaled insulin than with subcutaneous insulin in type 1 diabetes.

Inhaled insulin: overview of a novel route of insulin administration

Diabetes is a chronic disease characterized by inadequate insulin secretion with resulting hyperglycemia. Diabetes complications include both microvascular and macrovascular disease, both of which are affected by optimal diabetes control. Many individuals with diabetes rely on subcutaneous insulin administration by injection or continuous infusion to control glucose levels. Novel routes of insu...